– Injectable promethazine, an antihista- mine used in severe urticaria, can cause cutaneous necrosis and gangrene (Prescrire Int n° 109). Better to use injectable dexchlorpheniramine.
– Iron dextran carries a higher risk of hypersensitivity reactions than other injectable iron preparations (Prescrire Int n° 126).
– Tibolone, a synthetic steroid hormone used for post-menopausal hormone replacement therapy, has androgenic adverse effects, in addition to those of its oestrogen and progestin components (car- diovascular disease, breast and ovarian cancer, etc.) (Prescrire Int n° 111). When a woman opts for hormone therapy despite the risks, it is best to use the low- est-dose oestrogen + progestin combina- tion for the shortest possible time.
– Moxifloxacin is no more effective than other fluoroquinolones but carries a risk of Lyell’s syndrome, fulminant hepatitis, and more frequent cardiac disorders (Rev Prescrire n° 327);
– Duloxetine can cause liver damage (Prescrire Int n° 111);
– Ketoprofen gel carries a higher risk of cutaneous disorders than other topical NSAIDs (Prescrire Int n° 109, 112);
– Strontium ranelate can cause neuropsy- chiatric disorders and hypersensitivity reactions, including Lyell’s syndrome and Dress syndrome (drug reaction with eosinophilia and systemic symptoms.), and also venous thromboembolism (Prescrire Int n° 125);
